Abstract Text
Refractory gastroenteric fistulas, whether post-surgical or post-inflammatory, remain a therapeutic challenge. Autologous activated adipose-derived cells (ADSCs) injection is emerging as a minimally invasive option to promote fistula closure. The aim of this report is to describe two cases treated with ADSCs and evaluate safety and preliminary efficacy. Case 1 involved a 64-year-old female patient with a rectovaginal fistula following resection of the sigmoid and proximal rectum for perforated diverticulitis. Case 2 involved an 80-year-old male patient with a rectourethral fistula in the context of post-radiotherapy rectal ulceration for prostate adenocarcinoma. In both patients, autologous adipose tissue was harvested, processed, and injected endoscopically into the fistula tract. At 2.5-month follow-up, both patients showed complete clinical and endoscopic healing without adverse events.