Effective biliary drainage is critical in unresectable cholangiocarcinoma (CCA). The patient, a 53-year-old male, underwent several ERCP sessions for stent revisions and intraductal RFA. During the recent intervention with a novel linear EUS scope (EG-740UT, Fujifilm, Tokyo, Japan), a dilated duct in segment II was punctured using a 19G FNA needle, and a 0.025" curved-tip guidewire was advanced antegradely into the duodenum. The guidewire was retrieved with a pediatric biopsy forceps, achieving a single-scope transhepatic rendezvous. Using the same scope, multiple biliary branches were accessed, RFA was performed, and four 8F plastic stents were placed for optimal drainage. This case highlights the principle of single scope rendezvous with a novel linear EUS scope, which offers stability and momentum for retrograde and antegrade instrumentation to overcome complex hilar strictures.