Aims: Endoscopic ultrasonography-guided gallbladder drainage (EUS-GBD) with lumen-apposing metal stents (LAMS) is a minimally invasive option for managing high-risk, non-surgical patients with acute calculous cholecystitis. LAMS migration represents a potential adverse event. Methods: We report a case of complete intragallbladder LAMS migration following EUS-GBD. Results: A 74-year-old woman with significant comorbidities  and grade 2 acute cholecystitis underwent initial PTGBD, but was referred for persistent symptoms and bile leakage. After conversion to EUS-GBD, she returned one month later for planned stent removal. Endoscopy, EUS, and fluoroscopy revealed full intragallbladder migration. A repeat EUS-GBD with a LAMS enabled trans-LAMS extraction of the migrated stent and gallstone removal. Conclusion: EUS-guided LAMS retrieval may serve as an effective rescue strategy.