A 40-year-old woman in good clinical condition presented with recurrent abdominal pain. Abdominal computer tomography scan revealed an oval-shaped neoplasm measuring 2.5 x 3.2 cm with regular margins, located between the pancreatic head region, the gallbladder, and the first portion of the duodenum. The lesion exhibited a supradense fluid attenuation, predominantly peripheral enhancement with a partial spoke-wheel pattern, and caused mild compression of the duodenal lumen.Linear endoscopic ultrasound (EUS) showed a solid lesion measuring 2.6 × 2.7 cm with well-defined, regular margins and predominantly iso-hypoechoic texture, containing multiple internal anechoic areas. Following the intravenous administration of contrast agent, contrast enhancement was observed along with the appearance of some hyperechoic areas. Two passes with a 22- gauge needle were performed for histology of the solid component. Histology of the fine needle biopsy revealed a benign pancreatic schwannoma with immunostaining for S100 and Ki67 1-2%.Pancreatic schwannoma is an extremely rare tumor that originates from Schwann cells of the peripheral nerve sheaths within the pancreas. Less than 1% of pancreatic tumors are of mesenchymal origin, and among these, schwannomas account for only a small fraction. Malignant degeneration is rare but may be suspected in the presence of tumor size greater than 6.9 cm, vascular involvement, or invasion of adjacent organs. Diagnosis of pancreatic schwannoma is challenging due to its tendency to mimic other lesions of the pancreas [1]. EUS-FNB with S100 immunostaining should be considered the best preoperative diagnostic approach [2].