Colon cancer incidence demonstrates notable disparities across racial and gender groups. Certain populations, such as Black individuals, experience significantly higher risks, while gender differences further influence the likelihood of diagnosis. These disparities highlight the need for targeted interventions to address inequities and improve prevention and treatment strategies.

Data from the Nationwide Admission Database (HCUP) for 2019–2022 were analyzed, encompassing 1,748,576 adult hospital admissions. Patients included in the study had a principal diagnosis of colon cancer. Logistic regression was used to assess the relationships between race, gender, and the likelihood of colon cancer diagnosis. To address multicollinearity, Variance Inflation Factor (VIF) analysis was performed, and highly collinear variables were excluded. Race categories were encoded using one-hot encoding, and gender was incorporated as a predictor. The logistic regression model, developed with Statsmodels, evaluated the significance of predictors using z-values and p-values, quantifying the independent effects of race and gender while controlling for other variables.

Analysis revealed significant associations between race, gender, and colon cancer incidence. Black individuals had higher odds of being diagnosed with colon cancer, whereas other racial groups exhibited lower odds. Gender differences were also evident, with females demonstrating an increased likelihood of colon cancer diagnosis. These findings provide robust evidence of demographic disparities in colon cancer risk.

This study highlights the substantial influence of race and gender on colon cancer incidence. The elevated risk observed among African Americans underscores the need for targeted preventive measures, while the increased risk among females points to gender-specific factors requiring further investigation. These results stress the importance of incorporating race and gender considerations into strategies to reduce disparities in colon cancer burden and improve health equity