Intussusception  is defined as the invagination of one segment of the bowel into an immediately adjacent segment. In adults, it is uncommon and typically secondary to structural lesions such as tumors, polyps, Meckel’s diverticulum, postsurgical changes, or inflammatory conditions affecting the small bowel.

We present the case of a 19-year-old male followed in the Gastroenterology clinic for Crohn’s disease with upper gastrointestinal involvement (A1L4B1), treated with intravenous infliximab 5 mg/kg every 8 weeks. He had a prior admission for acute pancreatitis the previous year, attributed to active duodenal disease causing biliary obstruction.

Since the pancreatitis episode, the patient had experienced at least three episodes of severe abdominal pain, although laboratory markers—including C-reactive protein and fecal calprotectin—remained within normal range. He reported no diarrhea or extraintestinal manifestations. Given the possibility of subclinical disease activity, follow-up endoscopic studies (colonoscopy and upper endoscopy) were performed, both without significant findings.

Capsule endoscopy was subsequently conducted, demonstrating prolonged capsule retention for over 90 minutes in the mid-jejunum, with an image suggestive of intestinal intussusception. The mucosa proximal and distal to the intussusception appeared normal, and no lesions compatible with active Crohn’s disease were identified on the examination.

This case illustrates an exceptionally uncommon presentation of jejunal intussusception in a young adult with Crohn’s disease, occurring in the absence of biochemical, clinical, or endoscopic evidence of active inflammation, underscoring its diagnostic relevance.