Between 50–80% of patients with Systemic Sclerosis (SSc) develop gastric involvement, with gastroparesis being a common manifestation. We report a 36-year-old woman with SSc presenting with early satiety, postprandial vomiting, and significant weight loss. Endoscopy was normal, but contrast studies and gastric scintigraphy confirmed severe delayed gastric emptying. Dietary measures and optimized prokinetic therapy provided no relief. Due to refractory symptoms, G-POEM was performed under deep sedation. The procedure included a 15-mm mucosotomy, creation of a submucosal tunnel, pyloromyotomy, and closure with TTS clips, without complications. The patient was discharged after 48 hours and demonstrated sustained symptom resolution at 12 months. This case highlights G-POEM as a feasible therapeutic option for SSc-related gastroparesis.