To demonstrate the feasibility and real-world effectiveness of KAR and STER techniques for endoscopic resection of rectal subepithelial tumors, excluding neuroendocrine tumors (NETs).

A retrospective, multicenter study was conducted between January 2017 and October 2025. Data were collected using a standardized case report form (CRF) distributed to all participating centers. Descriptive and comparative analyses were performed to evaluate key outcomes, namely en bloc resection and adverse events, using R software (version 4.4.2).

Fifty-five patients were included (30 males, 55%), with a median age of 60 years (range 27–87), from 11 centers across 9 countries (Table). Diagnostic  pre-resection sampling was available in 26 cases (47.3%), most commonly obtained with EUS-FNA/FNB (41.8%). The main indications for resection were malignant potential (34.5%) and symptoms ( 34.5%) (Table). On EUS, the layer of origin was the muscularis propria in 27 cases (49.1%), the submucosa in 18 (32.7%), and the muscularis mucosa in 4 (7.3%). The majority of lesions demonstrated a partially (49.1%) or mainly endoluminal (38.2%) growth pattern, while a mainly extraluminal component was noted in 5 cases (9.1%). KAR was performed in 33 patients (60.0%), STER in 20 (36.4%), and 2 patients (3.6%) underwent knife-assisted hybrid techniques (circumferential incision with snare resection or full-thickness resection using a knife). Lesion size, location, distance from the dentate line, and growth pattern were comparable between groups, whereas muscularis propria origin was more frequent in STER [12/20 (60%)] than in KAR [14/33 (42%)], p = 0.005. The median distance from the dentate line was 6.0 cm in both groups, while the median tumor size was 20 mm (range 10–58) for KAR and 29 mm (range 9–64) for STER (p = 0.07). During dissection, the plane was purely submucosal in 18 cases (32%), intramuscular in 30 (55%), and extended into the perirectal fat in 7 (13%). All tumors were removed en bloc, with no septic complications. The predominant histology was GIST (34.5%), followed by leiomyoma (21.8%), lipoma (16.4%), and schwannoma (9.1%). Most GISTs were very low or low risk, and five patients received adjuvant Tyrosine Kinase Inhibitor therapy. The median procedure duration was 52.5 minutes (range 15–181). Two adverse events were recorded (3.6%), neither directly attributable to the endoscopic intervention: one urinary tract infection and one ischemic stroke requiring ICU admission. The median hospital stay was 1 day (range 0–7). Two early recurrences  in GIST cases were recorded, one managed endoscopically and the other under surveillance.

KAR and STER appear safe and effective for rectal subepithelial tumor resection. High en bloc rates, low complications, and short hospital stay support their minimally invasive role. Prospective studies are needed to confirm these retrospective findings.