EndoDrill is a novel electromechanical device designed for EUS-guided core biopsy, featuring a motorized handle and a flexible 17-gauge cylindrical tip that drills tissue rather than relying on conventional needle puncture. We report an unusual case where EndoDrill allowed easy one-step EUS-guided  sampling of an extrinsic rectal mass. A 72-year-old man undergoing CT urogram for hematuria was found to have a pelvic mass extending toward the rectum. Colonoscopy revealed a 3-cm extrinsic lesion eroding into the rectal lumen, located 10 cm from the anal verge. EUS-guided EndoDrill biopsies provided ample core tissue without adverse events. Histopathology and immunohistochemistry confirmed high-grade urothelial carcinoma. This case highlights the diagnostic potential of the novel EUS biopsy device in complex pelvic tumors.