We aim to assess the prognostic value of specific single-nucleotide polymorphisms (SNPs) in ANGPT2 (rs2442598) and NOS3 (rs2070744) genes concerning the development of EV. 

Fifty patients with HCV-related cirrhosis and varices found by endoscopy (Group I), fifty patients with HCV-related cirrhosis and no varices (Group II), and fifty healthy people as a control group (Group III) comprised the 150 participants in this study. 

For genetic factors, there was no significant differences in the genotype distribution or allele frequencies of ANGPT2 (rs2442598) and NOS3 (rs2070744) between patients with or without EV (p >0.05). However, significant differences were noted for ANGPT2 rs2442598 in relation to presence of varices, ascites, Child score, hypertension, ALT, and AST (p <0.05), while other parameters did not show significant differences (p >0.05). Similarly, for NOS3 rs2070744, significant differences were found in Child score, hypertension, ALT, and AST (p <0.05). 

ANGPT2 (rs2442598) variant is a promising non-invasive indicator to ensure that there are no varices with portal hypertension to predict absence of EV as a complication of cirrhosis.