We present a case of a 69-year-old man with anemia and weight loss. The gastroscopy revealed a 20 mm Gastrointestinal Stromal Tumor (GIST) in the posterior duodenum, confirmed by computed tomography (CT). Resection of the third portion of the duodenum with latero-lateral anastomosis was performed. After septic shock, a CT scan showed free fluid and pneumoperitoneum, suggestive of suture failure. A radiological drainage was placed. A gastroscopy confirmed dehiscence in the staple suture line and a xtack suture was used for repairing the leak, checking the complete seal with contrast.  One month later, follow-up CT and gastroscopy showed a decrease in the collection, with no extravasation or leakage, and the XTack correctly positioned. After the removal of the drainage, the patient was discharged, asymptomatic and with oral tolerance.