Introduction Verrucous carcinoma of the esophagus (VCE) is a rare, slowly growing malignant subentity of squamous cell carcinoma, first described in 1967. The most common symptoms are dysphagia, chest pain, and weight loss. The tumor typically shows local invasion; lymph node positivity is rare, and organic metastasis  hasn’t yet been described. Typical endoscopic findings include exophytic growth of a whitish warty mass, hyperkeratotic plaques, and candidal esophagitis. Histopathological findings include squamous proliferation and a so-called church spire appearance of hyperkeratosis and parakeratosis within the thickened spinous cell layer. Diagnosis is complex and may require multiple biopsies, up to endoscopic mucosal resection (EMR). An association with alcohol, tobacco, and human papillomavirus is discussed. Since its first description, just around sixty cases have been published. The most common treatment is esophagectomy. Other treatment options, such as (repeated) piecemeal EMR, endoscopic submucosal dissection (ESD), and radiochemotherapy, are documented in only a few case reports. Case description Thus, we present the first circumferential ESD using the double-tunneling technique in two patients with extended early VCE. A 77-year-old female patient and a 76-year-old male patient were recently diagnosed with early-stage VCE in our department. The endoscopic findings were an exophytic, cauliflower-like, warty mass measuring approximately 8 cm in length in the middle part of the esophagus (female patient) and a flat, hyperkeratotic lesion measuring approximately 10 cm in length in the middle and distal parts (male patient). Although the histology report showed only hyperkeratosis and candidal esophagitis, even in the snare resection specimens, the endoscopic image led to the decision to perform ESD in both cases. The procedure was performed using the double-tunneling technique over lengths of 9 and 12 cm, respectively, due to circumferential growth. The histology report of both resected specimens confirmed the diagnosis of mucosal VCE (female patient) and early submucosal VCE (male patient). The vertical margin was R0 in both patients. A microscopic edge-forming invasion of the upper horizontal margin on mucosal level was shown in both patients. Both patients received early post-interventional balloon dilatation of the esophagus two weeks after the procedure and corticosteroid treatment for four weeks. Clinical and endoscopic follow-up time is now two years and 15 months, respectively, without recurrence of carcinoma. Sequential balloon dilatation and temporary stent implantation due to post-procedural stenosis were required in the female patient. Conclusion ESD is a feasible and promising curative treatment option even for patients with extended early-stage VCE. Recurrence rates should be low regarding submucosal tumor clearance (vertical R0 resection). Esophageal stenosis, as the main post-procedural complication, must be considered. Early balloon dilatation and corticosteroid treatment are effective in reducing the risk of post-procedural stenosis.