Neurofibromas are benign peripheral nerve sheath tumors commonly associated with Neurofibromatosis Type 1 (NF1). Sporadic, solitary neurofibromas arising in the peripancreatic region are exceedingly rare and may present diagnostic challenges due to their resemblance to pancreatic malignancies on imaging. Accurate diagnosis is essential to guide management, as treatment strategies differ significantly between benign neurogenic tumors and aggressive pancreatic neoplasms. A 32-year-old male with no known comorbidities and no family history of malignancy underwent a routine annual wellness examination, during which an abdominal ultrasound was performed. The study incidentally revealed a few lobulated, heterogeneous, predominantly hypoechoic masses in the peripancreatic region, measuring 1.9 × 1.4 cm and 7.5 × 6.6 × 3.5 cm, with internal calcifications. The masses appeared to encase vascular structures, including the celiac trunk and portal confluence, raising concern for a malignant pancreatic process. Further evaluation with MRCP demonstrated an exophytic, peripherally enhancing lobulated mass arising from the pancreatic head and uncinate process. The lesion appeared T1 hypointense and T2 iso- to hyperintense and measured 5.4 × 6.5 × 7.1 cm (AP × T × CC). It encased the celiac trunk and superior mesenteric artery, compressed the portal confluence and superior mesenteric vein, and was intimately related to the inferior vena cava and the inferior margin of hepatic segment 4B and the caudate lobe. Due to these suspicious features, endoscopic ultrasound with fine needle biopsy was performed. Histopathologic evaluation revealed a spindle cell lesion, and immunohistochemical staining demonstrated negativity for CD117, DOG1, SMA, and desmin, with CD34 positivity highlighting perineural cells and diffuse S100 positivity. These findings were diagnostic of a low-grade, benign nerve sheath tumor, favoring neurofibroma. Peripancreatic neurofibromas are rare tumors, particularly in patients without neurofibromatosis type 1 (NF1), and they present a significant diagnostic challenge due to their ability to mimic pancreatic malignancy on imaging. In this case, the large size of the mass, its heterogeneous appearance, presence of calcifications, and particularly the encasement of major vascular structures created a strong radiologic impression of an aggressive pancreatic neoplasm such as pancreatic ductal adenocarcinoma or a malignant neuroendocrine tumor. These imaging features often prompt consideration of unresectable disease, and without tissue confirmation, patients may be subjected to unnecessary radical surgery or deemed inoperable. This case illustrates a rare presentation of a sporadic peripancreatic neurofibroma masquerading as a malignant pancreatic tumor due to its size and extensive vascular involvement. Comprehensive evaluation—including advanced imaging and EUS-guided biopsy with immunohistochemistry—is essential to avoid misdiagnosis and unnecessary radical surgery.